Structure of the HIV immature lattice allows for essential lattice remodeling within budded virions

Structure of the HIV immature lattice allows for essential lattice remodeling within budded virions

For HIV virions to become infectious, the immature lattice of Gag polyproteins attached to the virion membrane must be cleaved. Cleavage cannot initiate without the protease formed by the homo-dimerization of domains linked to Gag. However, only 5% of the Gag polyproteins, termed Gag-Pol, carry this...

Full description

Bibliographic Details
Main Authors: Sikao Guo, Ipsita Saha, Saveez Saffarian, Margaret E Johnson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
computational model
self-assembly
stochastic simulation
retroviral gag protein
Online Access:https://elifesciences.org/articles/84881

Internet

https://elifesciences.org/articles/84881

Similar Items