Atomic Simulation of the Binding of JAK1 and JAK2 with the Selective Inhibitor Ruxolitinib

Atomic Simulation of the Binding of JAK1 and JAK2 with the Selective Inhibitor Ruxolitinib

Rheumatoid arthritis belongs to the group of chronic systemic autoimmune diseases characterized by the development of destructive synovitis and extra-articular manifestations. Cytokines regulate a wide range of inflammatory processes involved in the pathogenesis of rheumatoid arthritis and contribut...

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Bibliographic Details
Main Authors: Maxim Kondratyev, Vladimir R. Rudnev, Kirill S. Nikolsky, Alexander A. Stepanov, Denis V. Petrovsky, Liudmila I. Kulikova, Arthur T. Kopylov, Kristina A. Malsagova, Anna L. Kaysheva
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
ruxolitinib
JAK inhibitor
rheumatoid arthritis
molecular modeling
Online Access:https://www.mdpi.com/1422-0067/23/18/10466

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https://www.mdpi.com/1422-0067/23/18/10466

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