Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synthesized using EDC in the presence of DMAP to provid...

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Bibliographic Details
Main Authors: Arun K. Ghosh, Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J. Anson, Emma K. Lendy, Connie Bonham, Devika Sirohi, Carlos A. Brito-Sierra, Shin-ichiro Hattori, Richard Kuhn, Hiroaki Mitsuya, Andrew D. Mesecar
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
indomethacin derivative
antiviral activity
COVID-19
3CLpro inhibitors
covalent inhibitors
ibuprofen derivative
Online Access:https://www.mdpi.com/1420-3049/26/19/5782

Internet

https://www.mdpi.com/1420-3049/26/19/5782

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