Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synthesized using EDC in the presence of DMAP to provid...

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Bibliographic Details
Main Authors:	Arun K. Ghosh, Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J. Anson, Emma K. Lendy, Connie Bonham, Devika Sirohi, Carlos A. Brito-Sierra, Shin-ichiro Hattori, Richard Kuhn, Hiroaki Mitsuya, Andrew D. Mesecar
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Molecules
Subjects:	indomethacin derivative antiviral activity COVID-19 3CLpro inhibitors covalent inhibitors ibuprofen derivative
Online Access:	https://www.mdpi.com/1420-3049/26/19/5782

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