7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity
Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2004-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390411919O.pdf |
| _version_ | 1818884818133319680 |
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| author | Opsenica Igor Terzić Nataša A. Opsenica Dejan M. Milhous Wilbur K. Šolaja Bogdan A. |
| author_facet | Opsenica Igor Terzić Nataša A. Opsenica Dejan M. Milhous Wilbur K. Šolaja Bogdan A. |
| author_sort | Opsenica Igor |
| collection | DOAJ |
| description | Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin. |
| first_indexed | 2024-12-19T15:55:35Z |
| format | Article |
| id | doaj.art-f42d5f3c67f3426a82aaa02b27131044 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-19T15:55:35Z |
| publishDate | 2004-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-f42d5f3c67f3426a82aaa02b271310442022-12-21T20:15:05ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212004-01-01691191992210.2298/JSC0411919O0352-51390411919O7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activityOpsenica Igor0Terzić Nataša A.1Opsenica Dejan M.2Milhous Wilbur K.3Šolaja Bogdan A.4Institute of Chemistry, Technology and Metallurgy, Belgrade, Serbia and MontenegroInstitute of Chemistry, Technology and Metallurgy, Belgrade, Serbia and MontenegroInstitute of Chemistry, Technology and Metallurgy, Belgrade, Serbia and MontenegroDevision of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, USAFaculty of Chemistry, BelgradeSeveral C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin.http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390411919O.pdfmixed tetraoxanemalariaplasmodium falciparumgem-dihydroperoxide |
| spellingShingle | Opsenica Igor Terzić Nataša A. Opsenica Dejan M. Milhous Wilbur K. Šolaja Bogdan A. 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity Journal of the Serbian Chemical Society mixed tetraoxane malaria plasmodium falciparum gem-dihydroperoxide |
| title | 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity |
| title_full | 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity |
| title_fullStr | 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity |
| title_full_unstemmed | 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity |
| title_short | 7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity |
| title_sort | 7 8 15 16 tetraoxa dispiro 5 2 5 2 hexadecane 3 carboxylic acid derivatives and their antimalarial activity |
| topic | mixed tetraoxane malaria plasmodium falciparum gem-dihydroperoxide |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390411919O.pdf |
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