Jaw Bone Invasion of Oral Squamous Cell Carcinoma Is Associated with Osteoclast Count and Expression of Its Regulating Proteins in Patients and Organoids

Jaw Bone Invasion of Oral Squamous Cell Carcinoma Is Associated with Osteoclast Count and Expression of Its Regulating Proteins in Patients and Organoids

Aims: Oral squamous cell carcinoma (OSCC) frequently invades the jaw. The exact mechanism of bone invasion remains unclear. This study investigates (premature) osteoclasts and the expression of its differentiation regulating proteins RANKL, OPG and RANK in patients with OSCC. Methods: Resection spec...

Full description

Bibliographic Details
Main Authors: Willem W. B. de Kort, Wisse E. Haakma, Robert J. J. van Es, Debby Gawlitta, Else Driehuis, Merel Gansevoort, Stefan M. Willems
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Journal of Clinical Medicine
Subjects:
head and neck squamous cell carcinoma
bone invasion
mandibular invasion
osteoclasts
RANKL
OPG
Online Access:https://www.mdpi.com/2077-0383/12/18/6035

Internet

https://www.mdpi.com/2077-0383/12/18/6035

Similar Items