TRPV2-induced Ca2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma

TRPV2-induced Ca2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma

Abstract Background Myeloma bone disease (MBD) can cause bone destruction and increase the level of Ca2+ concentration in the bone marrow microenvironment by stimulating osteoclastic differentiation. Nevertheless, the relationships between MBD and highly efficient stimuli of Ca2+ in multiple myeloma...

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Bibliographic Details
Main Authors: Hua Bai, Huayuan Zhu, Qing Yan, Xuxing Shen, Xiupan Lu, Juejin Wang, Jianyong Li, Lijuan Chen
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Cell Communication and Signaling
Subjects:
Myeloma bone disease
TRPV2
Calcium
Osteoimmunology
Osteoclastogenesis
Online Access:http://link.springer.com/article/10.1186/s12964-018-0280-8

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http://link.springer.com/article/10.1186/s12964-018-0280-8

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