Transferrin Saturation/Hepcidin Ratio Discriminates <i>TMPRSS6</i>-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia

Transferrin Saturation/Hepcidin Ratio Discriminates <i>TMPRSS6</i>-Related Iron Refractory Iron Deficiency Anemia from Patients with Multi-Causal Iron Deficiency Anemia

Pathogenic <i>TMPRSS6</i> variants impairing matriptase-2 function result in inappropriately high hepcidin levels relative to body iron status, leading to iron refractory iron deficiency anemia (IRIDA). As diagnosing IRIDA can be challenging due to its genotypical and phenotypical hetero...

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Bibliographic Details
Main Authors: Hilde van der Staaij, Albertine E. Donker, Dirk L. Bakkeren, Jan M. J. I. Salemans, Lisette A. A. Mignot-Evers, Marlies Y. Bongers, Jeanne P. Dieleman, Tessel E. Galesloot, Coby M. Laarakkers, Siem M. Klaver, Dorine W. Swinkels
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
IRIDA
iron deficiency anemia
<i>TMPRSS6</i>
hepcidin
transferrin
transferrin saturation/hepcidin ratio
Online Access:https://www.mdpi.com/1422-0067/23/3/1917

Internet

https://www.mdpi.com/1422-0067/23/3/1917

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