Glycoengineering of Darbepoetin-α in CHO-DG44 Cells through Overexpression of α-2,3-sialyl-transferase and CMP-sialic Acid Transporter

Sialic acid plays a very important role in determining the circulation life span of glycoprotein in various organisms. Therefore, having a high content of sialic acid is needed by glycoprotein therapeutic agents to be able to function as desired. For example, Darbepoetin (DPO), the 5 N-linked erythr...

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Bibliographic Details
Main Authors: Adi Santoso, Endah Puji Septisetyani, Ratna Dwi Ramadani, Yana Rubiyana, Pekik Wiji Prasetyaningrum, Popi Hadi Wisnuwardhani, Arizah Kusumawati, Neny Nuraini
Format: Article
Language:English
Published: Bogor Agricultural University 2022-01-01
Series:Hayati Journal of Biosciences
Online Access:https://journal.ipb.ac.id/index.php/hayati/article/view/39142