Glycoengineering of Darbepoetin-α in CHO-DG44 Cells through Overexpression of α-2,3-sialyl-transferase and CMP-sialic Acid Transporter
Sialic acid plays a very important role in determining the circulation life span of glycoprotein in various organisms. Therefore, having a high content of sialic acid is needed by glycoprotein therapeutic agents to be able to function as desired. For example, Darbepoetin (DPO), the 5 N-linked erythr...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Bogor Agricultural University
2022-01-01
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Series: | Hayati Journal of Biosciences |
Online Access: | https://journal.ipb.ac.id/index.php/hayati/article/view/39142 |