Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa

Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa

Abstract Background Retinitis pigmentosa (RP) is a hereditary retinal disease which leads to visual impairment. The onset and progression of RP has physiological consequences that affects the ocular environment. Some of the key non-genetic factors which hasten the retinal degeneration in RP include...

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Bibliographic Details
Main Authors: K. Varsha Mohan, Alaknanda Mishra, Abaranjitha Muniyasamy, Prakriti Sinha, Parul Sahu, Ashwani Kesarwani, Kshama Jain, Perumal Nagarajan, Vinod Scaria, Manisha Agarwal, Naseem S. Akhter, Chanda Gupta, Pramod Upadhyay
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Retinitis pigmentosa
Tight junction protein (TJP)
Blood brain barrier (BRB)
Immune infiltration
Transforming growth factor—beta 1 (TGF-B1)
Retinal Degeneration 1 (rd1)
Online Access:https://doi.org/10.1186/s13023-022-02528-x

Internet

https://doi.org/10.1186/s13023-022-02528-x

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