Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation

Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation

Background Despite its potential utility in delivering direct tumor killing and in situ whole-cell tumor vaccination, tumor cryoablation produces highly variable and unpredictable clinical response, limiting its clinical utility. The mechanism(s) driving cryoablation-induced local antitumor immunity...

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Bibliographic Details
Main Authors: Sung Hee Choi, Mohammad Alshebremi, Suzanne L Tomchuck, Jay T Myers, Daniel T Kingsley, Saada Eid, Muta Abiff, Melissa Bonner, Shahrazad T Saab, Alex Yee-Chen Huang
Format: Article
Language:English
Published: BMJ Publishing Group 2023-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/8/e006608.full

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https://jitc.bmj.com/content/11/8/e006608.full

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