Status of research on natural protein tyrosine phosphatase 1B inhibitors as potential antidiabetic agents: Update

Status of research on natural protein tyrosine phosphatase 1B inhibitors as potential antidiabetic agents: Update

Protein tyrosine phosphatase 1B (PTP1B) is a crucial therapeutic target for multiple human diseases comprising type 2 diabetes (T2DM) and obesity because it is a seminal part of a negative regulator in both insulin and leptin signaling pathways. PTP1B inhibitors increase insulin receptor sensitivity...

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Bibliographic Details
Main Authors: Zhenyang Liu, Hongwei Gao, Ziyu Zhao, Mengrui Huang, Shengnan Wang, Jiuyu Zhan
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Protein tyrosine phosphatase 1B (PTP1B)
Inhibitor
Natural product
Type 2 diabetes
Structure-activity relationship (SAR)
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013798

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http://www.sciencedirect.com/science/article/pii/S0753332222013798

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