Eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood pressure in spontaneously hypertensive rats via inducing vasorelaxation

Eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood pressure in spontaneously hypertensive rats via inducing vasorelaxation

Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) suppresses protein translation. We previously reported eEF2K expression was upregulated in mesenteric arteries (MA) from spontaneously hypertensive rats (SHR). We have recently revealed A484954, an eEF2K inhibitor, acutely suppressed vasopressor a...

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Bibliographic Details
Main Authors: Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Eukaryotic elongation factor 2 kinase
Hypertension
Endothelium
Nitric oxide
β-adrenergic receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300712

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http://www.sciencedirect.com/science/article/pii/S1347861320300712

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