Discovery of Unannotated Small Open Reading Frames in Streptococcus pneumoniae D39 Involved in Quorum Sensing and Virulence Using Ribosome Profiling

Discovery of Unannotated Small Open Reading Frames in Streptococcus pneumoniae D39 Involved in Quorum Sensing and Virulence Using Ribosome Profiling

ABSTRACT Streptococcus pneumoniae, an opportunistic human pathogen, is the leading cause of community-acquired pneumonia and an agent of otitis media, septicemia, and meningitis. Although genomic and transcriptomic studies of S. pneumoniae have provided detailed perspectives on gene content and expr...

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Bibliographic Details
Main Authors: Irina Laczkovich, Kyle Mangano, Xinhao Shao, Adam J. Hockenberry, Yu Gao, Alexander Mankin, Nora Vázquez-Laslop, Michael J. Federle
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
ribosome profiling
Streptococcus pneumoniae D39
small proteins
small open reading frames
virulence
quorum sensing
Online Access:https://journals.asm.org/doi/10.1128/mbio.01247-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01247-22

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