A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus

A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus

ABSTRACT During aerobic growth, S. aureus relies on acetate overflow metabolism, a process where glucose is incompletely oxidized to acetate, for its bioenergetic needs. Acetate is not immediately captured as a carbon source and is excreted as waste by cells. The underlying factors governing acetate...

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Detalhes bibliográficos
Principais autores: Nabia Shahreen, Jongsam Ahn, Adil Alsiyabi, Niaz Bahar Chowdhury, Dhananjay Shinde, Sujata S. Chaudhari, Kenneth W. Bayles, Vinai C. Thomas, Rajib Saha
Formato: Artigo
Idioma:English
Publicado em: American Society for Microbiology 2025-01-01
coleção:mSphere
Assuntos:
overflow metabolism
redox imbalance
thermodynamic bottleneck
membrane crowding
acetate overflow
Acesso em linha:https://journals.asm.org/doi/10.1128/msphere.00883-24

Internet

https://journals.asm.org/doi/10.1128/msphere.00883-24

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