TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation

TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation

Abstract Background Recognition of viral invasion by innate antiviral immune system triggers activation of the type I interferon (IFN-I) and proinflammatory signaling pathways. Subsequently, IFN-I induction regulates expression of a group of genes known as IFN-I-stimulated genes (ISGs) to block vira...

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Bibliographic Details
Main Authors: Shulong Zu, Chunfeng Li, Lili Li, Yong-Qiang Deng, Xiang Chen, Dan Luo, Qing Ye, Yi-Jiao Huang, Xiao-Feng Li, Rong-Rong Zhang, Nina Sun, Xianqi Zhang, Saba R. Aliyari, Karin Nielsen-Saines, Jae U. Jung, Heng Yang, Cheng-Feng Qin, Genhong Cheng
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cell & Bioscience
Subjects:
TRIM22
Zika virus
Infection
Nonstructural protein
Ubiquitination
Online Access:https://doi.org/10.1186/s13578-022-00872-w

Internet

https://doi.org/10.1186/s13578-022-00872-w

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