Ligand-gated ion channel P2X7 regulates hypoxia-induced factor-1α mediated pain induced by dental pulpitis in the medullary dorsal horn

Ligand-gated ion channel P2X7 regulates hypoxia-induced factor-1α mediated pain induced by dental pulpitis in the medullary dorsal horn

Dental pulpitis often induces severe pain, and the molecular immune response is remarkable in both peripheral and central nervous system. Accumulating evidence indicates that activated microglia in the medullary dorsal horn (MDH) contribute to dental pulpitis induced pain. The P2X7 receptor plays an...

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Bibliographic Details
Main Authors: Jing Zhang, Jialin Si, Rongrong Liang, Yuxin Lu, Hongwei Shang, Xinwei Li, Shukai Sun, Li-an Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
P2X7
HIF-1α
pain
dental pulpitis
medullary dorsal horn
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1015751/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.1015751/full

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