Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis

Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis

Abstract Background E1A-associated 300-kDa protein (P300), an endogenous histone acetyltransferase, contributes to modifications of the chromatin landscape of genes involved in multiple cardiovascular diseases. Ferroptosis of vascular smooth muscle cells (VSMCs) is a novel pathological mechanism of...

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Bibliographic Details
Main Authors: Juan Shi, Qun-Hui Wang, Xiang Wei, Bo Huo, Jian-Nan Ye, Xin Yi, Xin Feng, Ze-Min Fang, Ding-Sheng Jiang, Ming-Jia Ma
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Molecular Medicine
Subjects:
Vascular smooth muscle cells
Ferroptosis
P300
HIF-1α
HMOX1
P53
Online Access:https://doi.org/10.1186/s10020-023-00694-7

Internet

https://doi.org/10.1186/s10020-023-00694-7

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