In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking

In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking

Abstract Coagulation Factor Xa (FXa) is the crucial enzyme at the convergent point of the intrinsic and extrinsic coagulation pathways. The inhibition of FXa is an effective approach against thrombotic diseases. In the present study, a specific strategy is reported to discover 10 novel FXa inhibitor...

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Bibliographic Details
Main Authors: Yinglan Pu, Hui Liu, Yeheng Zhou, Jiale Peng, Yaping Li, Penghua Li, Yingying Li, Xingyong Liu, Li Zhang
Format: Article
Language:English
Published: SpringerOpen 2017-06-01
Series:Natural Products and Bioprospecting
Subjects:
FXa
Thrombotic diseases
Pharmacophore
Docking
Online Access:http://link.springer.com/article/10.1007/s13659-017-0126-x

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http://link.springer.com/article/10.1007/s13659-017-0126-x

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