Design, synthesis, and cytotoxic evaluation of quinazoline derivatives bearing triazole-acetamides

Design, synthesis, and cytotoxic evaluation of quinazoline derivatives bearing triazole-acetamides

A novel series of quinazoline-based agents bearing triazole-acetamides 8a-l were designed and synthesized. All the obtained compounds were tested for in vitro cytotoxic activities against three human cancer cell lines named HCT-116, MCF-7, and HepG2, as well as a normal cell line WRL-68 after 48 and...

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Bibliographic Details
Main Authors: Keyvan Pedrood, Fahimeh Taayoshi, Ali Moazzam, Aida Iraji, Ali Yavari, Samira Ansari, Sayed Mahmoud Sajjadi-Jazi, Mohammad Reza Mohajeri-Tehrani, Nadia Garmsiri, Vahid Haghpanah, Meysam Soleymanibadi, Bagher Larijani, Haleh Hamedifar, Neda Adibpour, Mohammad Mahdavi
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Heliyon
Subjects:
Anticancer activity
Click chemistry
Docking
Quinazoline
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023007351

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http://www.sciencedirect.com/science/article/pii/S2405844023007351

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