Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis

Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis

ABSTRACTRenal proximal tubular cells are highly vulnerable to different types of assaults during filtration and reabsorption, leading to acute renal dysfunction and eventual chronic kidney diseases (CKD). The chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but...

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Bibliographic Details
Main Authors: Xing-Qiang Dong, Li-Kai Chu, Xu Cao, Qian-Wei Xiong, Yi-Ming Mao, Ching-Hsien Chen, Yun-Li Bi, Jun Liu, Xiang-Ming Yan
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Redox Report
Subjects:
Glutathione metabolism
renal tubular
apoptosis
ferroptosis
JAK/STAT3
Cisplatin
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2022.2152607

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https://www.tandfonline.com/doi/10.1080/13510002.2022.2152607

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