Design of a randomized controlled phase III study of dose dense methotrexate, vinblastine, doxorubicin and cisplatin (dd-MVAC) or gemcitabine and cisplatin (GC) as peri-operative chemotherapy for patients with locally advanced transitional cell cancer of the bladder. The French GETUG/AFU V05 VESPER trial

Design of a randomized controlled phase III study of dose dense methotrexate, vinblastine, doxorubicin and cisplatin (dd-MVAC) or gemcitabine and cisplatin (GC) as peri-operative chemotherapy for patients with locally advanced transitional cell cancer of the bladder. The French GETUG/AFU V05 VESPER trial

The main objective of the French GETUG/AFU V05 VESPER randomized phase III study was to assess the efficacy of dd-MVAC and GC in term of progression-free survival in patients for whom chemotherapy has been decided, before or after surgery.A total of 500 patients have been randomized in 28 reference...

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Main Authors: Christian Pfister, Valentin Harter, Yves Allory, François Radvanyi, Stéphane Culine, G. Grawis, G. Pignot, A. Flechon, J.P. Fendler, C. Chevreau, M. Soulie, H. Mahammedi, L. Guy, B. Laguerre, G. Verhoest, A. Guillot, N. Mottet, F. Joly, A. Doerfler, S. Abadie-Lacourtoisie, A.R. Azzouzi, P. Mongiat, L. Geoffrois, P. Eschwege, F. Di Fiore, G. Roubaud, J.L. Hoepffner, P. Barthelemy, H. Lang, E. Voog, E. Mandron, J.M. Tourani, C. Serrrate, A. Colau, C. Saldana, A. de La Taille, T. Nguyen, F. Kleinclauss, Y. Loriot, J. Irani, J.C. Eymard, S. Larre, O. Huillard, M. Zerbib, F. Rolland, J. Rigaud, N. Houede, S. Droupy, G. Malouf, M. Roupret, M. El Demery, C. Legon, S. Vieillot, N. Letang, T. Lharidon, N. Gaschignard, W. Hilgers, J.L. Davin
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Contemporary Clinical Trials Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S245186542030020X

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http://www.sciencedirect.com/science/article/pii/S245186542030020X

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