Parameter Identification for a Model of Neonatal Fc Receptor-Mediated Recycling of Endogenous Immunoglobulin G in Humans

Parameter Identification for a Model of Neonatal Fc Receptor-Mediated Recycling of Endogenous Immunoglobulin G in Humans

Salvage of endogenous immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) is implicated in many clinical areas, including therapeutic monoclonal antibody kinetics, patient monitoring in IgG multiple myeloma, and antibody-mediated transplant rejection. There is a clear clinical need for a fully...

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Bibliographic Details
Main Authors: Felicity Kendrick, Neil D. Evans, Oscar Berlanga, Stephen J. Harding, Michael J. Chappell
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
biological systems
lumped-parameter systems
immunoglobulin G
neonatal Fc receptor
parameter estimation
structural identifiability
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00674/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00674/full

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