Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation

Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation

Introduction: Opioids are the leading cause of overdose death in the United States, accounting for almost 70,000 deaths in 2020. Deep brain stimulation (DBS) is a promising new treatment for substance use disorders. Here, we hypothesized that VTA DBS would modulate both the dopaminergic and respirat...

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Bibliographic Details
Main Authors: Jason Yuen, Abhinav Goyal, Aaron E. Rusheen, Abbas Z. Kouzani, Michael Berk, Jee Hyun Kim, Susannah J. Tye, Osama A. Abulseoud, Tyler S. Oesterle, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Yoonbae Oh, Hojin Shin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
substance use disorder
deep brain stimulation
nucleus accumbens
ventral tegmental area
oxycodone
dopamine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1199655/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1199655/full

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