On-demand chlorine dioxide solution enhances odontoblast differentiation through desulfation of cell surface heparan sulfate proteoglycan and subsequent activation of canonical Wnt signaling

On-demand chlorine dioxide solution enhances odontoblast differentiation through desulfation of cell surface heparan sulfate proteoglycan and subsequent activation of canonical Wnt signaling

Heparan sulfate proteoglycans (HSPGs) surround the surface of odontoblasts, and their modification affects their affinity for Wnt ligands. This study proposes applying Matching Transformation System® (MA-T), a novel chlorinated oxidant, to enhance dentinogenesis. MA-T treatment in odontoblasts decre...

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Bibliographic Details
Main Authors: Toshihiro Inubushi, Nag Priyanka, Masakatsu Watanabe, Yusuke Takahashi, Shinnosuke Kusano, Hiroshi Kurosaka, Silvana Papagerakis, Petros Papagerakis, Mikako Hayashi, Takashi Yamashiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
heparan sulfate proteoglycans
chlorinated oxidant
MA-T
DSPP
DMP1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1271455/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1271455/full

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