Death switch for gene therapy: application to erythropoietin transgene expression

Death switch for gene therapy: application to erythropoietin transgene expression

The effectiveness of the caspase-9-based artificial "death switch" as a safety measure for gene therapy based on the erythropoietin (Epo) hormone was tested in vitro and in vivo using the chemical inducer of dimerization, AP20187. Plasmids encoding the dimeric murine Epo, the tetracycline-...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: D.S. Souza, D.M. Spencer, T.S.I. Salles, M.A. Salomão, E. Payen, Y. Beuzard, H.F. Carvalho, F.F. Costa, S.T.Olalla Saad
Format: Artykuł
Język:English
Wydane: Associação Brasileira de Divulgação Científica 2010-07-01
Seria:Brazilian Journal of Medical and Biological Research
Hasła przedmiotowe:
Gene therapy
Erythropoietin
Death switch
Caspase 9
AP20187
Anemia
Dostęp online:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700005

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700005

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