Loss of Primary Cilia Potentiates <i>BRAF/MAPK</i> Pathway Activation in Rhabdoid Colorectal Carcinoma: A Series of 21 Cases Showing Ciliary Rootlet CoiledCoil (<i>CROCC</i>) Alterations

Loss of Primary Cilia Potentiates <i>BRAF/MAPK</i> Pathway Activation in Rhabdoid Colorectal Carcinoma: A Series of 21 Cases Showing Ciliary Rootlet CoiledCoil (<i>CROCC</i>) Alterations

A rhabdoid colorectal tumor (RCT) is a rare cancer with aggressive clinical behavior. Recently, it has been recognized as a distinct disease entity, characterized by genetic alterations in the <i>SMARCB1</i> and Ciliary Rootlet Coiled-Coil (<i>CROCC</i>). We here investigate...

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Bibliographic Details
Main Authors: Andrea Remo, Federica Grillo, Luca Mastracci, Michele Simbolo, Matteo Fassan, Maria Paola Cecchini, Giuseppe Miscio, Antonio Sassano, Paola Parente, Alessandro Vanoli, Giovanna Sabella, Guido Giordano, Emanuele Damiano Urso, Luigi Cerulo, Aldo Scarpa, Francesco Fiorica, Massimo Pancione
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Genes
Subjects:
rhabdoid colorectal tumors
rare cancers
Ciliary Rootlet Coiled-Coil (CROCC)
<i>SMARCB1</i>
Online Access:https://www.mdpi.com/2073-4425/14/5/984

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https://www.mdpi.com/2073-4425/14/5/984

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