Identification and experimental validation of key extracellular proteins as potential targets in intervertebral disc degeneration

Identification and experimental validation of key extracellular proteins as potential targets in intervertebral disc degeneration

Aims: This study aimed, through bioinformatics analysis and in vitro experiment validation, to identify the key extracellular proteins of intervertebral disc degeneration (IDD). Methods: The gene expression profile of GSE23130 was downloaded from the Gene Expression Omnibus (GEO) database. Extracell...

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Bibliographic Details
Main Authors: Guang-Zhi Zhang, Lei Li, Zhang-Bin Luo, Cang-Yu Zhang, Yong-Gang Wang, Xue-Wen Kang
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-09-01
Series:Bone & Joint Research
Subjects:
intervertebral disc degeneration
extracellular proteins
differentially expressed genes
protein-protein interactions
bioinformatics analysis
collagen
gene expression
micrornas (mirnas)
cytoscape
gene expression profiling
t-test
nucleus pulposus tissues
nucleus pulposus
intervertebral disc (ivd)
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.129.BJR-2022-0369.R2

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.129.BJR-2022-0369.R2

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