Aryl hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding.

Aryl hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding.

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-made environmental toxicants, has emerged as an endogenous regulator of cyclooxygenase-2 (Cox-2) by a mechanism that is poorly understood. In this study, we first used AhR-deficient (AhR(-/-) ) primary...

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Bibliographic Details
Main Authors: Michela Zago, Jared A Sheridan, Parameswaran Nair, Angela Rico de Souza, Imed-Eddine Gallouzi, Simon Rousseau, Sergio Di Marco, Qutayba Hamid, David H Eidelman, Carolyn J Baglole
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3785509?pdf=render

Internet

http://europepmc.org/articles/PMC3785509?pdf=render

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