HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel

HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel

Abstract High Mobility Group A1 (HMGA1) is an architectural chromatin factor involved in the regulation of gene expression and a master regulator in Triple Negative Breast Cancer (TNBC). In TNBC, HMGA1 is overexpressed and coordinates a gene network that controls cellular processes involved in tumou...

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Bibliographic Details
Main Authors: Michela Sgubin, Silvia Pegoraro, Ilenia Pellarin, Gloria Ros, Riccardo Sgarra, Silvano Piazza, Gustavo Baldassarre, Barbara Belletti, Guidalberto Manfioletti
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04843-4

Internet

https://doi.org/10.1038/s41419-022-04843-4

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