Protocol for the hyperinsulinemic euglycemic clamp to measure glucose kinetics in rats

Summary: In rats, cannulation of the jugular vein and the carotid artery precedes the use of the hyperinsulinemic euglycemic clamp to determine insulin sensitivity in vivo. Here, we present a vascular surgery protocol to allow the infusion of substances via the vein and the collection of blood sampl...

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Bibliographic Details
Main Authors: Sandra Pereira, Margaret K. Hahn, Bailey Humber, Talha Chaudhry, Sally Wu, Sri Mahavir Agarwal, Nanka Dimitrova, Adria Giacca
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166724003083