A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation

A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation

Abstract SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss and depletion on DNA methylation across cancer types and tumorigenesis is current...

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Bibliographic Details
Main Authors: Hira Javaid, Alessandro Barberis, Olga Chervova, Isar Nassiri, Vitaly Voloshin, Yusuke Sato, Seishi Ogawa, Benjamin Fairfax, Francesca Buffa, Timothy C. Humphrey
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Cancer
Subjects:
DNA methylation
SETD2
H3K36me3
Renal cancer biomarker
Machine learning biomarker
Online Access:https://doi.org/10.1186/s12885-023-11162-0

Internet

https://doi.org/10.1186/s12885-023-11162-0

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