A programmable pAgo nuclease with RNA target-cleavage specificity from the mesophilic bacterium Verrucomicrobia

A programmable pAgo nuclease with RNA target-cleavage specificity from the mesophilic bacterium Verrucomicrobia

Argonaute (Ago) proteins are conserved programmable nucleases present in eukaryotes and prokaryotes and provide defense against mobile genetic elements. Almost all characterized pAgos prefer to cleave DNA targets. Here, we describe a novel pAgo from Verrucomicrobia bacterium (VbAgo) that can specifi...

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Hlavní autoři: Liu Qi, Chen Wanping, Zhang Yue, Hu Fengyang, Jiang Xiaoman, Wang Fei, Liu Yang, Ma Lixin
Médium: Článek
Jazyk:English
Vydáno: China Science Publishing & Media Ltd. 2023-07-01
Edice:Acta Biochimica et Biophysica Sinica
Témata:
RNA target specificity
<italic>Verrucomicrobia</italic> bacterium
prokaryotic argonaute
programmable nucleases
On-line přístup:https://www.sciengine.com/doi/10.3724/abbs.2023110

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023110

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