A programmable pAgo nuclease with RNA target-cleavage specificity from the mesophilic bacterium Verrucomicrobia

A programmable pAgo nuclease with RNA target-cleavage specificity from the mesophilic bacterium Verrucomicrobia

Argonaute (Ago) proteins are conserved programmable nucleases present in eukaryotes and prokaryotes and provide defense against mobile genetic elements. Almost all characterized pAgos prefer to cleave DNA targets. Here, we describe a novel pAgo from Verrucomicrobia bacterium (VbAgo) that can specifi...

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Bibliographic Details
Main Authors: Liu Qi, Chen Wanping, Zhang Yue, Hu Fengyang, Jiang Xiaoman, Wang Fei, Liu Yang, Ma Lixin
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-07-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
RNA target specificity
<italic>Verrucomicrobia</italic> bacterium
prokaryotic argonaute
programmable nucleases
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023110

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023110

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