Gut microbiota affects sensitivity to immune-mediated isoniazid-induced liver injury

Gut microbiota affects sensitivity to immune-mediated isoniazid-induced liver injury

Isoniazid (INH) is a highly effective single and/or combined first-line anti-tuberculosis (anti-TB) therapy drug, and the hepatotoxicity greatly limits its clinical application. INH-induced liver injury (INH-DILI) is a typical immune-mediated idiosyncratic drug-induced liver injury. Existing mechani...

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Bibliographic Details
Main Authors: Na Liu, Jinfeng Liu, Binjie Zheng, Xiangchang Zeng, Zixin Ye, Xinyi Huang, Wenhui Liu, Yating Liu, Qing Fang, Lulu Chen, Tai Rao, Dongsheng Ouyang
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Isoniazid
Liver injury
Gut microbiota
Immune response
Adaptation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223001889

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http://www.sciencedirect.com/science/article/pii/S0753332223001889

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