Lacticaseibacillus casei Strain T21 Attenuates Clostridioides difficile Infection in a Murine Model Through Reduction of Inflammation and Gut Dysbiosis With Decreased Toxin Lethality and Enhanced Mucin Production

Lacticaseibacillus casei Strain T21 Attenuates Clostridioides difficile Infection in a Murine Model Through Reduction of Inflammation and Gut Dysbiosis With Decreased Toxin Lethality and Enhanced Mucin Production

Clostridioides difficile is a major cause of diarrhea in patients with antibiotic administration. Lacticaseibacillus casei T21, isolated from a human gastric biopsy, was tested in a murine C. difficile infection (CDI) model and colonic epithelial cells (Caco-2 and HT-29). Daily administration of L....

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Bibliographic Details
Main Authors: Wimonrat Panpetch, Pornpimol Phuengmaung, Thanya Cheibchalard, Naraporn Somboonna, Asada Leelahavanichkul, Somying Tumwasorn
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Microbiology
Subjects:
Lacticaseibacillus casei T21
probiotics
proinflammatory cytokines
Clostridioides difficile
gut dysbiosis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.745299/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.745299/full

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