Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors

Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors

When combined with anti-PD-1, monoclonal antibodies (mAbs) against GARP:TGF-β1 complexes induced more frequent immune-mediated rejections of CT26 and MC38 murine tumors than anti-PD-1 alone. In both types of tumors, the activity of anti-GARP:TGF-β1 mAbs resulted from blocking active TGF-β1 productio...

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Bibliographic Details
Main Authors: Charlotte Bertrand, Pierre Van Meerbeeck, Grégoire de Streel, Noora Vaherto-Bleeckx, Fatima Benhaddi, Loïc Rouaud, Agnès Noël, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
GARP
TGF-β1
cancer immunotherapy
immunosuppression
immune checkpoint inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.704050/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.704050/full

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