The Mechanistic Perspective of Bilobetin Protective Effects against Cisplatin-Induced Testicular Toxicity: Role of Nrf-2/Keap-1 Signaling, Inflammation, and Apoptosis

The Mechanistic Perspective of Bilobetin Protective Effects against Cisplatin-Induced Testicular Toxicity: Role of Nrf-2/Keap-1 Signaling, Inflammation, and Apoptosis

Cisplatin (CP) is a productive anti-tumor used to treat numerous tumors. However, multiple toxicities discourage prolonged use, especially toxicity on the reproductive system. This experiment was mapped out to determine the potential therapeutic impact of Bilobetin on CP-induced testicular damage. H...

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Bibliographic Details
Main Authors: Walaa A. Negm, Aya H. El-Kadem, Ismail A. Hussein, Moneerah J. Alqahtani
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
bilobetin
<i>Cycas thouarsii</i>
caspase-3
cisplatin
keap-1
Ki67
Online Access:https://www.mdpi.com/2227-9059/10/5/1134

Internet

https://www.mdpi.com/2227-9059/10/5/1134

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