Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long‐Acting PTH Analog (LA‐PTH)

Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long‐Acting PTH Analog (LA‐PTH)

ABSTRACT Prolonged signaling at the parathyroid hormone receptor 1 (PTHR1) correlates with the capacity of a ligand to bind to a G protein‐independent receptor conformation (R0). As long‐acting PTH (LA‐PTH) ligands hold interest as potential treatments for hypoparathyroidism (HP), we explored the st...

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Bibliographic Details
Main Authors: Hiroshi Noda, Makoto Okazaki, Eri Joyashiki, Tatsuya Tamura, Yoshiki Kawabe, Ashok Khatri, Harald Jueppner, John T Potts Jr, Thomas J Gardella, Masaru Shimizu
Format: Article
Language:English
Published: Oxford University Press 2020-07-01
Series:JBMR Plus
Subjects:
PARATHYROID‐RELATED DISORDERS
DISORDERS OF CALCIUM/PHOSPHATE METABOLISM
HORMONE REPLACEMENT/RECEPTOR MODULATORS
THERAPEUTICS, PRECLINICAL STUDIES
ANIMAL MODELS, PTH/ViT D/FGF23
CELL/TISSUE SIGNALING
Online Access:https://doi.org/10.1002/jbm4.10367

Internet

https://doi.org/10.1002/jbm4.10367

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