Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes

Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes

Abstract Background Epidemiological data suggests statins could reduce the risk of dementia, and more specifically, Alzheimer’s disease (AD). Pre-clinical data suggests statins reduce the risk of dementia through their pleiotropic effects rather than their cholesterol lowering effects. While AD is a...

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Bibliographic Details
Main Authors: Erica M. Weekman, Sherika N. Johnson, Colin B. Rogers, Tiffany L. Sudduth, Kevin Xie, Qi Qiao, David W. Fardo, Teodoro Bottiglieri, Donna M. Wilcock
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Neuroinflammation
Subjects:
Hyperhomocysteinemia
Vascular contributions to cognitive impairment and dementia
Atorvastatin
Neuroinflammation
Microglia
Microhemorrhages
Online Access:https://doi.org/10.1186/s12974-023-02883-x

Internet

https://doi.org/10.1186/s12974-023-02883-x

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