Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas

Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas

Summary: Aberrant RAS signaling activation is common in cancers with even few Ras mutations, indicating alternative dysregulation other than genetic mutations. We identified a Ras GTPase-activating gene RASA5/SYNGAP1, at the common 6p21.3 deletion, methylated/downregulated in multiple carcinomas and...

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Main Authors: Lili Li, Yichao Fan, Xin Huang, Jie Luo, Lan Zhong, Xing-sheng Shu, Li Lu, Tingxiu Xiang, Anthony T.C. Chan, Winnie Yeo, Ceshi Chen, Wai Yee Chan, Richard L. Huganir, Qian Tao
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219303864

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http://www.sciencedirect.com/science/article/pii/S2589004219303864

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