Differential Influence of Sample Sex and Neuronal Maturation on mRNA and Protein Transport in Induced Human Neurons

Differential Influence of Sample Sex and Neuronal Maturation on mRNA and Protein Transport in Induced Human Neurons

Nucleocytoplasmic transport (NCT) across thenuclear envelope (NE) is tightly regulated in eukaryotic cells and iscritical for maintaining cellular homeostasis. Its dysregulationleads to aging and neurodegeneration. Because they maintainaging-associated hallmarks, directly reprogrammed neurons from h...

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Bibliographic Details
Main Authors: Baojin Ding, Masuma Akter, Chun-Li Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
reprogrammed human neurons
nucleocytoplasmic transport
nuclear mRNA export
fluorescence in situ hybridization (FISH)
protein nuclear transport
sex as a biological variable (SABV)
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00046/full

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https://www.frontiersin.org/article/10.3389/fnmol.2020.00046/full

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