Heat shock protein 90 inhibition attenuates inflammation in models of atopic dermatitis: a novel mechanism of action

Heat shock protein 90 inhibition attenuates inflammation in models of atopic dermatitis: a novel mechanism of action

BackgroundHeat shock protein 90 (HSP90) is an important chaperone supporting the function of many proinflammatory client proteins. Recent studies indicate HSP90 inhibition may be a novel mechanism of action for inflammatory skin diseases; however, this has not been explored in atopic dermatitis (AD)...

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Bibliographic Details
Main Authors: Hakim Ben Abdallah, Anne Bregnhøj, Gautam Ghatnekar, Lars Iversen, Claus Johansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
Hsp90
atopic dermatitis
RGRN-305
small molecule
keratinocytes
MC903 mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289788/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289788/full

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