Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
Abstract N6-methyladenosine (m6A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression and phenotypic changes by controlling RNA fate. Insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) preferentially function as m6A eff...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-023-00499-0 |
| _version_ | 1797774059450138624 |
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| author | Tian-Yu Zhu Lian-Lian Hong Zhi-Qiang Ling |
| author_facet | Tian-Yu Zhu Lian-Lian Hong Zhi-Qiang Ling |
| author_sort | Tian-Yu Zhu |
| collection | DOAJ |
| description | Abstract N6-methyladenosine (m6A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression and phenotypic changes by controlling RNA fate. Insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) preferentially function as m6A effector proteins, promoting stability and translation of m6A-modified RNAs. IGF2BPs, particularly IGF2BP1 and IGF2BP3, are widely recognized as oncofetal proteins predominantly expressed in cancer rather than normal tissues, playing a critical role in tumor initiation and progression. Consequently, IGF2BPs hold potential for clinical applications and serve as a good choice for targeted treatment strategies. In this review, we discuss the functions and mechanisms of IGF2BPs as m6A readers and explore the therapeutic potential of targeting IGF2BPs in human cancer. |
| first_indexed | 2024-03-12T22:15:27Z |
| format | Article |
| id | doaj.art-f46848098a7c47b1aa1ea9014672ebd6 |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-03-12T22:15:27Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-f46848098a7c47b1aa1ea9014672ebd62023-07-23T11:21:24ZengBMCBiomarker Research2050-77712023-06-0111111510.1186/s40364-023-00499-0Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potentialTian-Yu Zhu0Lian-Lian Hong1Zhi-Qiang Ling2Zhejiang Cancer HospitalZhejiang Cancer HospitalZhejiang Cancer HospitalAbstract N6-methyladenosine (m6A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression and phenotypic changes by controlling RNA fate. Insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) preferentially function as m6A effector proteins, promoting stability and translation of m6A-modified RNAs. IGF2BPs, particularly IGF2BP1 and IGF2BP3, are widely recognized as oncofetal proteins predominantly expressed in cancer rather than normal tissues, playing a critical role in tumor initiation and progression. Consequently, IGF2BPs hold potential for clinical applications and serve as a good choice for targeted treatment strategies. In this review, we discuss the functions and mechanisms of IGF2BPs as m6A readers and explore the therapeutic potential of targeting IGF2BPs in human cancer.https://doi.org/10.1186/s40364-023-00499-0IGF2BPsm6ACancerTherapeutic target |
| spellingShingle | Tian-Yu Zhu Lian-Lian Hong Zhi-Qiang Ling Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential Biomarker Research IGF2BPs m6A Cancer Therapeutic target |
| title | Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential |
| title_full | Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential |
| title_fullStr | Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential |
| title_full_unstemmed | Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential |
| title_short | Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential |
| title_sort | oncofetal protein igf2bps in human cancer functions mechanisms and therapeutic potential |
| topic | IGF2BPs m6A Cancer Therapeutic target |
| url | https://doi.org/10.1186/s40364-023-00499-0 |
| work_keys_str_mv | AT tianyuzhu oncofetalproteinigf2bpsinhumancancerfunctionsmechanismsandtherapeuticpotential AT lianlianhong oncofetalproteinigf2bpsinhumancancerfunctionsmechanismsandtherapeuticpotential AT zhiqiangling oncofetalproteinigf2bpsinhumancancerfunctionsmechanismsandtherapeuticpotential |