Hexavalent chromium induces apoptosis in human liver (HepG2) cells via redox imbalance

Hexavalent chromium induces apoptosis in human liver (HepG2) cells via redox imbalance

Hexavalent chromium, Cr(VI), is an environmental toxicant and is associated with hepatotoxicity. However, very little is known about the intracellular antioxidant defense mechanism against Cr(VI)-induced cytotoxicity in hepatocytes. In the present study, we cultured human liver (HepG2) cells in the...

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Bibliographic Details
Main Authors: Joydeep Das, Abhijit Sarkar, Parames C. Sil
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Toxicology Reports
Subjects:
Chromium
Hepatocytes
Oxidative stress
Mitochondrial damage
Apoptosis
Antioxidant signaling
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750015000451

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http://www.sciencedirect.com/science/article/pii/S2214750015000451

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