Role of Chemokine Cxcl12a in Mediating the Stimulatory Effects of Ethanol on Embryonic Development of Subpopulations of Hypocretin/Orexin Neurons and Their Projections

Role of Chemokine Cxcl12a in Mediating the Stimulatory Effects of Ethanol on Embryonic Development of Subpopulations of Hypocretin/Orexin Neurons and Their Projections

Studies in zebrafish and rats show that embryonic ethanol exposure at low-moderate concentrations stimulates hypothalamic neurons expressing hypocretin/orexin (Hcrt) that promote alcohol consumption, effects possibly involving the chemokine Cxcl12 and its receptor Cxcr4. Our recent studies in zebraf...

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Bibliographic Details
Main Authors: Nushrat Yasmin, Adam D. Collier, Abdul R. Abdulai, Olga Karatayev, Boyi Yu, Milisia Fam, Sarah F. Leibowitz
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
chemokine
Cxcl12
hypocretin
orexin
ethanol
prenatal alcohol exposure
Online Access:https://www.mdpi.com/2073-4409/12/10/1399

Internet

https://www.mdpi.com/2073-4409/12/10/1399

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