Varying molecular interactions explain aspects of crowder-dependent enzyme function of a viral protease.

Biochemical processes in cells, including enzyme-catalyzed reactions, occur in crowded conditions with various background macromolecules occupying up to 40% of cytoplasm's volume. Viral enzymes in the host cell also encounter such crowded conditions as they often function at the endoplasmic ret...

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Bibliographic Details
Main Authors: Natalia Ostrowska, Michael Feig, Joanna Trylska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-04-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1011054