Validation and Demonstration of an Atmosphere-Temperature-pH-Controlled Stirred Batch Reactor System for Determination of (Nano)Material Solubility and Dissolution Kinetics in Physiological Simulant Lung Fluids

Validation and Demonstration of an Atmosphere-Temperature-pH-Controlled Stirred Batch Reactor System for Determination of (Nano)Material Solubility and Dissolution Kinetics in Physiological Simulant Lung Fluids

In this study, we present a dissolution test system that allows for the testing of dissolution of nano- and micrometer size materials under highly controlled atmospheric composition (O<sub>2</sub> and CO<sub>2</sub>), temperature, and pH. The system enables dissolution testin...

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Bibliographic Details
Main Authors: Else Holmfred, Katrin Loeschner, Jens J. Sloth, Keld Alstrup Jensen
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Nanomaterials
Subjects:
Nanomaterials
abiotic in vitro testing
physiological fluids
batch reactor
inductively coupled plasma-mass spectrometry
Online Access:https://www.mdpi.com/2079-4991/12/3/517

Internet

https://www.mdpi.com/2079-4991/12/3/517

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