Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases

Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases

Liver sinusoidal endothelial cells have a gatekeeper function in liver homeostasis by permitting substrates from the bloodstream into the space of Disse and regulating hepatic stellate cell activation status. Maintenance of LSEC's highly specialized phenotype is crucial for liver homeostasis. D...

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Bibliographic Details
Main Authors: Stefaan Verhulst, Elise Anne van Os, Vincent De Smet, Nathalie Eysackers, Inge Mannaerts, Leo A. van Grunsven
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Medicine
Subjects:
LSEC
acute liver injury
single cell RNA sequencing (scRNAseq)
primary cells
NAFLD (non-alcoholic fatty liver disease)
non-alcoholic steatohepatitis (NASH)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.750044/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.750044/full

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