ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma

ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma

Abstract Background Sustained activation of hepatocyte growth factor (HGF)/c-MET signaling is a major driver of hepatocellular carcinoma (HCC) progression, but underlying mechanism is unclear. ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 2 (ASAP2) can reportedly activate GTPases and promote...

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Bibliographic Details
Main Authors: Xiao-Lu Ma, Yan-Yan Nie, Su-Hong Xie, Hui Zheng, Ying Tong, Yan-Chun Wang, Tian-Qing Yan, Xin Meng, Jia-Zhen Cao, Wei-Guo Tang, Lin Guo, Ren-Quan Lu
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Experimental Hematology & Oncology
Subjects:
Hepatocellular carcinoma
Epithelial-mesenchymal transition
c-MET signaling
ASAP2
CIN85
Online Access:https://doi.org/10.1186/s40164-023-00393-3

Internet

https://doi.org/10.1186/s40164-023-00393-3

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