Single Cell RNA-Sequence Analyses Reveal Uniquely Expressed Genes and Heterogeneous Immune Cell Involvement in the Rat Model of Intervertebral Disc Degeneration

Single Cell RNA-Sequence Analyses Reveal Uniquely Expressed Genes and Heterogeneous Immune Cell Involvement in the Rat Model of Intervertebral Disc Degeneration

Intervertebral disc (IVD) degeneration is characterized by a loss of cellularity, and changes in cell-mediated activity that drives anatomic changes to IVD structure. In this study, we used single-cell RNA-sequencing analysis of degenerating tissues of the rat IVD following lumbar disc puncture. Two...

Full description

Bibliographic Details
Main Authors: Milad Rohanifar, Sade W. Clayton, Garrett W.D. Easson, Deepanjali S. Patil, Frank Lee, Liufang Jing, Marcos N. Barcellona, Julie E. Speer, Jordan J. Stivers, Simon Y. Tang, Lori A. Setton
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Applied Sciences
Subjects:
intervertebral disc degeneration
single-cell RNA sequencing
cell type
Online Access:https://www.mdpi.com/2076-3417/12/16/8244

Internet

https://www.mdpi.com/2076-3417/12/16/8244

Similar Items